About the Authors

Vincenzo Libri

v.libri@imperial.ac.uk

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom

Andrew P. Brown

Affiliation Imanova Centre for Imaging Sciences, London, United Kingdom

Giulio Gambarota

Affiliation GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom

Jonathan Haddad

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America

Gregory S. Shields

Affiliation GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom

Helen Dawes

Affiliation Movement Sciences Group, Oxford Brookes University, Oxford, United Kingdom

David J. Pinato

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom

Ethan Hoffman

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America

Peter J. Elliot

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America

George P. Vlasuk

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America

Eric Jacobson

Affiliation Sirtris Pharmaceuticals, A GSK Company, Cambridge, Massachusetts, United States of America

Martin R. Wilkins

Affiliation The National Institute for Health Research (NIHR)–Wellcome Trust Imperial College Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, United Kingdom

Paul M. Matthews

Affiliations GSK Clinical Imaging Centre, GlaxoSmithKline, Imperial College, London, United Kingdom, Division of Brain Sciences, Department of Medicine, Imperial College, London, United Kingdom

Competing Interests

At the time this publication was written, JH, EH, PEGPV and EJ were employed by Sirtris Pharmaceuticals, a GlaxoSmithKline company developing SR2104 and related molecules. APB, GG, and PMM were employed by GlaxoSmithKline Research and Development (GSK R&D), Ltd. VL was employed by GSK R&D until April 2009. APB is currently employed by Imanova, Centre of Imaging Sciences, London, UK. The other authors declared no conflicts of interest. The above competing interests do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PMM PJE. Performed the experiments: VL APB GG GSS HD. Analyzed the data: JH EH. Contributed reagents/materials/analysis tools: PJE EJ. Wrote the paper: VL EJ MRW DJP GPV.