The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex

Rachel Doidge; Saloni Mittal; Akhmed Aslam; G. Sebastiaan Winkler

doi:10.1371/journal.pone.0051331

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Peer-reviewed

Research Article

The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex

Rachel Doidge,

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Saloni Mittal,

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Akhmed Aslam,

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
G. Sebastiaan Winkler

* E-mail: sebastiaan.winkler@nottingham.ac.uk

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯

The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex

Rachel Doidge,
Saloni Mittal,
Akhmed Aslam,
G. Sebastiaan Winkler

Published: December 7, 2012
https://doi.org/10.1371/journal.pone.0051331

About the Authors

Rachel Doidge

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

Saloni Mittal

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

Akhmed Aslam

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

G. Sebastiaan Winkler

* E-mail: sebastiaan.winkler@nottingham.ac.uk

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RD GSW. Performed the experiments: RD SM AA. Analyzed the data: RD SM AA GSW. Contributed reagents/materials/analysis tools: RD SM AA GSW. Wrote the paper: RD GSW.

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Transfection
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Messenger RNA
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Small interfering RNA
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Cell proliferation
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Untranslated regions
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Amino acid substitution
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Plasmid construction
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Gene expression
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