About the Authors

Rasmus Ribel-Madsen

rrm@sund.ku.dk

Affiliations Steno Diabetes Center, Gentofte, Denmark, Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Mario F. Fraga

Affiliation Department of Immunology and Oncology, National Centre for Biotechnology, CNB-CSIC, Madrid, Spain

Stine Jacobsen

Affiliation Steno Diabetes Center, Gentofte, Denmark

Jette Bork-Jensen

Affiliation Steno Diabetes Center, Gentofte, Denmark

Ester Lara

Affiliation Department of Cancer Epigenetics, Spanish National Cancer Research Centre, Madrid, Spain

Vincenzo Calvanese

Affiliation Department of Cancer Epigenetics, Spanish National Cancer Research Centre, Madrid, Spain

Agustin F. Fernandez

Affiliation Cancer Epigenetics Laboratory, Instituto Universitario de Oncologia del Principado de Asturias, HUCA, Universidad de Oviedo, Oviedo, Spain

Martin Friedrichsen

Affiliation Steno Diabetes Center, Gentofte, Denmark

Birgitte F. Vind

Affiliation Department of Endocrinology, Odense University Hospital, Odense, Denmark

Kurt Højlund

Affiliation Department of Endocrinology, Odense University Hospital, Odense, Denmark

Henning Beck-Nielsen

Affiliation Department of Endocrinology, Odense University Hospital, Odense, Denmark

Manel Esteller

Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain

Allan Vaag

Affiliations Steno Diabetes Center, Gentofte, Denmark, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark

Pernille Poulsen

Affiliation Novo Nordisk A/S, Søborg, Denmark

Competing Interests

RR-M MFF, SJ, JB-J, EL, VC, AFF, MF, BFV, KH, HB-N, ME and AV have declared that no competing interests exist. The authors have read the journal's policy and have the following financial conflict: PP is employed in Novo Nordisk A/S. There are no patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PP MFF AV KH HB-N. Performed the experiments: RR-M AFF MFF EL VC SJ BFV PP AV. Analyzed the data: RR-M JB-J AFF MF. Contributed reagents/materials/analysis tools: MFF AFF ME. Wrote the paper: RR-M PP AV.