About the Authors

Jing Han

Contributed equally to this work with: Jing Han, Aaron M. Lynne

Affiliation Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

Aaron M. Lynne

Contributed equally to this work with: Jing Han, Aaron M. Lynne

Affiliations Department of Biological Sciences, Sam Houston State University, Huntsville, Texas, United States of America, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Donna E. David

Affiliation Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Hailin Tang

Current address: Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

Affiliation ICF International Incorporation at NCTR/FDA, Jefferson, Arkansas, United States of America

Joshua Xu

Current address: Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

Affiliation ICF International Incorporation at NCTR/FDA, Jefferson, Arkansas, United States of America

Rajesh Nayak

Affiliation Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America

Pravin Kaldhone

Affiliation Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Catherine M. Logue

Affiliation Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa, United States of America

Steven L. Foley

Steven.Foley@fda.hhs.gov

Affiliations Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Competing Interests

Co-authors HT and JX worked for ICF International Incorporation, which provided bioinformatics support to the National Center for Toxicological Research. This affiliation did not influence the overall design and implementation of the study and does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JH AML DED RN SLF. Performed the experiments: JH AML DED HT JX PK SLF. Analyzed the data: JH AML DED HT JX PK SLF. Contributed reagents/materials/analysis tools: HT JX RN CML SLF. Wrote the paper: JH AML DED RN HT JX PK CML SLF.