About the Authors

Mari Aikio

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland

Ilkka Alahuhta

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland

Sini Nurmenniemi

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland

Juho Suojanen

Affiliation Institute of Dentistry, University of Helsinki, Helsinki, Finland

Riitta Palovuori

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland

Susanna Teppo

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland

Timo Sorsa

Affiliation Institute of Dentistry, University of Helsinki, Helsinki, Finland

Carlos López-Otín

Affiliation Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain

Taina Pihlajaniemi

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland

Tuula Salo

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland, Oulu University Hospital, Oulu, Finland

Ritva Heljasvaara

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Oulu, Finland

Pia Nyberg

pia.nyberg@oulu.fi

Affiliations Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland, Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland, Oulu University Hospital, Oulu, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA JS TuS TP TP TiS RH PN. Performed the experiments: MA IA SN JS RP ST PN. Analyzed the data: MA IA SN JS ST TuS RH PN. Contributed reagents/materials/analysis tools: MA RP CLO PN. Wrote the paper: MA TuS CLO TP TiS RH PN.