About the Authors
- Christopher E. Heise
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* E-mail: heise.christopher@gene.com (CEH); michelle.arkin@ucsf.edu (MRA)
Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America
- Jeremy Murray
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Affiliation Department of Structural Biology, Genentech, Inc., South San Francisco, California, United States of America
- Katherine E. Augustyn
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- Brandon Bravo
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Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America
- Preeti Chugha
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- Frederick Cohen
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Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
- Anthony M. Giannetti
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Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America
- Paul Gibbons
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Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
- Rami N. Hannoush
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Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America
- Brian R. Hearn
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- Priyadarshini Jaishankar
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- Cuong Q. Ly
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Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
- Kinjalkumar Shah
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Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America
- Karen Stanger
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Affiliation Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, California, United States of America
- Micah Steffek
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Affiliation Department of Structural Biology, Genentech, Inc., South San Francisco, California, United States of America
- Yinyan Tang
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- Xianrui Zhao
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Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
- Joseph W. Lewcock
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Affiliation Department of Neuroscience, Genentech, Inc., South San Francisco, California, United States of America
- Adam R. Renslo
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Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
- John Flygare
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Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
- Michelle R. Arkin
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* E-mail: heise.christopher@gene.com (CEH); michelle.arkin@ucsf.edu (MRA)
Affiliation Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America
Competing Interests
Several authors of this manuscript are employed by Genentech, Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. There are no patents, products in development, or marketed products to declare.
Author Contributions
Conceived and designed the experiments: CEH AMG RNH JM MS PG KEA FC BRH ARR MRA. Performed the experiments: CEH KEA BB AMG RNH K. Shah K. Stanger YT JM MS PG PC FC BRH PJ CQL XZ ARR. Analyzed the data: CEH KEA BB AMG RNH K. Shah K. Stanger YT JM PG MS FC BRH ARR MRA. Contributed reagents/materials/analysis tools: PG XZ CQL FC. Wrote the paper: CEH JM MRA FC ARR BRH AMG PG. Led the project team: JF JWL ARR MRA.