Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

Saad Khan; Ashley W. Rammeloo; John J. Heikkila

doi:10.1371/journal.pone.0050547

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Open Access

Peer-reviewed

Research Article

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

Saad Khan ,

Contributed equally to this work with: Saad Khan, Ashley W. Rammeloo

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
⨯
Ashley W. Rammeloo ,

Contributed equally to this work with: Saad Khan, Ashley W. Rammeloo

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
⨯
John J. Heikkila

* E-mail: heikkila@sciborg.uwaterloo.ca

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
⨯

Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

Saad Khan,
Ashley W. Rammeloo,
John J. Heikkila

Published: November 30, 2012
https://doi.org/10.1371/journal.pone.0050547

About the Authors

Saad Khan

Contributed equally to this work with: Saad Khan, Ashley W. Rammeloo

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada

Ashley W. Rammeloo

Contributed equally to this work with: Saad Khan, Ashley W. Rammeloo

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada

John J. Heikkila

* E-mail: heikkila@sciborg.uwaterloo.ca

Affiliation Department of Biology, University of Waterloo, Waterloo, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JJH SK AWR. Performed the experiments: SK AWR. Analyzed the data: JJH SK AWR. Contributed reagents/materials/analysis tools: JJH. Wrote the paper: JJH SK AWR.

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Heat shock response
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Actins
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Cytoskeleton
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Proteasomes
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Xenopus
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Imaging techniques
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Cytoplasmic staining
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Nuclear staining
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