A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α2A-Adrenergic Receptor

Yi Fan; Chunman Li; Jianhui Guo; Gang Hu; Guangyu Wu

doi:10.1371/journal.pone.0050416

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Open Access

Peer-reviewed

Research Article

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α_2A-Adrenergic Receptor

Yi Fan,

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Chunman Li,

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Jianhui Guo,

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯
Gang Hu,

Affiliation Department of Pharmacology, Nanjing Medical University, Nanjing, China
⨯
Guangyu Wu

* E-mail: guwu@georgiahealth.edu

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America
⨯

A Single Lys Residue on the First Intracellular Loop Modulates the Endoplasmic Reticulum Export and Cell-Surface Expression of α_2A-Adrenergic Receptor

Yi Fan,
Chunman Li,
Jianhui Guo,
Gang Hu,
Guangyu Wu

Published: December 5, 2012
https://doi.org/10.1371/journal.pone.0050416

About the Authors

Yi Fan

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Chunman Li

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Jianhui Guo

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Gang Hu

Affiliation Department of Pharmacology, Nanjing Medical University, Nanjing, China

Guangyu Wu

* E-mail: guwu@georgiahealth.edu

Affiliation Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GW YF. Performed the experiments: YF CL JG. Analyzed the data: GW YF CL. Contributed reagents/materials/analysis tools: YF GH. Wrote the paper: GW YF.

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G protein coupled receptors
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Transfection
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Cell binding
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Intracellular receptors
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Flow cytometry
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Confocal microscopy
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Endoplasmic reticulum
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HeLa cells
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