About the Authors

Vijay Ramakrishnan

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Teresa Kimlinger

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Jessica Haug

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Utkarsh Painuly

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Linda Wellik

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Timothy Halling

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

S. Vincent Rajkumar

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Shaji Kumar

kumar.shaji@mayo.edu

Affiliation The Divisions of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

Competing Interests

SK received research support from Celgene, Millennium, Novartis, Merck, Cephalon, Genzyme and Bayer. SK is on the advisory board of Merck. MK-2206 was provided by Merck. & Co., Inc. (Whitehouse Station, NJ). There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: VR SVR SK. Performed the experiments: VR TK JH UP LW TH. Analyzed the data: VR SVR SK. Contributed reagents/materials/analysis tools: SVR SK. Wrote the paper: VR SVR SK.