About the Authors

Lei Yu

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Chunming Rao

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Xinchang Shi

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Yonghong Li

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Kai Gao

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Xuguang Li

Affiliation Biologics and Genetic Therapies Directorate, Health Canada, Tunney's Pasture, Ottawa, Canada

Junzhi Wang

wangjz@nicpbp.org.cn

Affiliation National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People’s Republic of China

Competing Interests

The authors have the following interests: The work presented in this report is the subject of a pending patent filed by National Institutes for Food and Drug Control, Beijing, China. There are no further patents, products in development or marketed products to declare. This does not alter the authors adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JW. Performed the experiments: LY. Contributed reagents/materials/analysis tools: CR. Wrote the paper: LY. Participated in the experiments (Rabbit aortic strips test): XS. Guided the experiments: YL KG. Data analysis (Indirect immunofluorescence staining and flow cytometry): YL. Data analysis (competitive ELISA): KG. Guided the writing and revised the manuscript: XL.