Plasmodium falciparum UvrD Helicase Translocates in 3′ to 5′ Direction, Colocalizes with MLH and Modulates Its Activity through Physical Interaction

Moaz Ahmad; Abulaish Ansari; Mohammed Tarique; Akash Tripathi Satsangi; Renu Tuteja

doi:10.1371/journal.pone.0049385

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Open Access

Peer-reviewed

Research Article

Plasmodium falciparum UvrD Helicase Translocates in 3′ to 5′ Direction, Colocalizes with MLH and Modulates Its Activity through Physical Interaction

Moaz Ahmad ,

Contributed equally to this work with: Moaz Ahmad, Abulaish Ansari

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
⨯
Abulaish Ansari ,

Contributed equally to this work with: Moaz Ahmad, Abulaish Ansari

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
⨯
Mohammed Tarique,

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
⨯
Akash Tripathi Satsangi,

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
⨯
Renu Tuteja

* E-mail: renu@icgeb.res.in

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
⨯

Plasmodium falciparum UvrD Helicase Translocates in 3′ to 5′ Direction, Colocalizes with MLH and Modulates Its Activity through Physical Interaction

Moaz Ahmad,
Abulaish Ansari,
Mohammed Tarique,
Akash Tripathi Satsangi,
Renu Tuteja

Published: November 21, 2012
https://doi.org/10.1371/journal.pone.0049385

About the Authors

Moaz Ahmad

Contributed equally to this work with: Moaz Ahmad, Abulaish Ansari

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Abulaish Ansari

Contributed equally to this work with: Moaz Ahmad, Abulaish Ansari

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Mohammed Tarique

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Akash Tripathi Satsangi

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Renu Tuteja

* E-mail: renu@icgeb.res.in

Affiliation Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RT. Performed the experiments: MA AA MT ATS. Analyzed the data: RT MA AA. Contributed reagents/materials/analysis tools: RT. Wrote the paper: RT AA.

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Helicases
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Plasmodium
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Adenosine triphosphatase
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Sequence motif analysis
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Enzymes
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Malarial parasites
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Enzyme-linked immunoassays
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DNA helicases
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