About the Authors

Edwin T. Parlevliet

Contributed equally to this work with: Edwin T. Parlevliet, Yanan Wang

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Yanan Wang

Contributed equally to this work with: Edwin T. Parlevliet, Yanan Wang

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Janine J. Geerling

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Janny P. Schröder-Van der Elst

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Kristen Picha

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Karyn O'Neil

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Vedrana Stojanovic-Susulic

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Tatiana Ort

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Louis M. Havekes

Affiliations Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Gaubius Laboratory, Netherlands Organization for Applied Scientific Research-Metabolic Health Research, Leiden, The Netherlands

Johannes A. Romijn

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Hanno Pijl

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Patrick C. N. Rensen

P.C.N.Rensen@lumc.nl

Affiliation Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Competing Interests

This research was supported by a grant from Janssen Research & Development. The CNTO3649 used in this study is a Janssen product. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ETP YW PCNR. Performed the experiments: ETP YW. Analyzed the data: JJG JPS-vdE KP KO. Contributed reagents/materials/analysis tools: KP KO VS-S TO JAR PCNR. Wrote the paper: ETP YW PCNR. Reviewed this manuscript: JJG JPS-vdE KP KO VS-S TO LMH HP JAR.