ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Helena C. Christianson; Toin H. van Kuppevelt; Mattias Belting

doi:10.1371/journal.pone.0049092

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Open Access

Peer-reviewed

Research Article

ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Helena C. Christianson,

Affiliation Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden
⨯
Toin H. van Kuppevelt,

Affiliation Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Mattias Belting

* E-mail: Mattias.Belting@med.lu.se

Affiliations Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden, Skåne University Hospital and Oncology Clinic, Lund, Sweden
⨯

ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Helena C. Christianson,
Toin H. van Kuppevelt,
Mattias Belting

Published: November 9, 2012
https://doi.org/10.1371/journal.pone.0049092

About the Authors

Helena C. Christianson

Affiliation Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden

Toin H. van Kuppevelt

Affiliation Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands

Mattias Belting

* E-mail: Mattias.Belting@med.lu.se

Affiliations Department of Clinical Sciences, Section of Oncology, Lund University and Skåne University Hospital, Lund, Sweden, Skåne University Hospital and Oncology Clinic, Lund, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HCC TVK MB. Performed the experiments: HCC MB. Analyzed the data: HCC TVK MB. Contributed reagents/materials/analysis tools: TVK. Wrote the paper: HCC TVK MB.

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Cancer treatment
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MAPK signaling cascades
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Heparin
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Cancers and neoplasms
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Hypoxia
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Cell binding
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Breast cancer
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Glioblastoma multiforme
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