Fibrillin-1 Mutations Causing Weill-Marchesani Syndrome and Acromicric and Geleophysic Dysplasias Disrupt Heparan Sulfate Interactions

Stuart A. Cain; Amanda McGovern; Andrew K. Baldwin; Clair Baldock; Cay M. Kielty

doi:10.1371/journal.pone.0048634

Loading metrics

Open Access

Peer-reviewed

Research Article

Fibrillin-1 Mutations Causing Weill-Marchesani Syndrome and Acromicric and Geleophysic Dysplasias Disrupt Heparan Sulfate Interactions

Stuart A. Cain ,

* E-mail: stuart.a.cain@manchester.ac.uk

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Amanda McGovern,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Andrew K. Baldwin,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Clair Baldock,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Cay M. Kielty

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯

Fibrillin-1 Mutations Causing Weill-Marchesani Syndrome and Acromicric and Geleophysic Dysplasias Disrupt Heparan Sulfate Interactions

Stuart A. Cain,
Amanda McGovern,
Andrew K. Baldwin,
Clair Baldock,
Cay M. Kielty

Published: November 2, 2012
https://doi.org/10.1371/journal.pone.0048634

About the Authors

Stuart A. Cain

* E-mail: stuart.a.cain@manchester.ac.uk

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Amanda McGovern

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Andrew K. Baldwin

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Clair Baldock

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Cay M. Kielty

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAC CB CMK. Performed the experiments: SAC AM CB. Analyzed the data: SAC AM AKB CB CMK. Contributed reagents/materials/analysis tools: SAC AM CB. Wrote the paper: SAC CB CMK.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Heparin
Is the Subject Area "Heparin" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Deletion mutation
Is the Subject Area "Deletion mutation" applicable to this article?

Thanks for your feedback.
Binding analysis
Is the Subject Area "Binding analysis" applicable to this article?

Thanks for your feedback.
Monomers
Is the Subject Area "Monomers" applicable to this article?

Thanks for your feedback.
Protein domains
Is the Subject Area "Protein domains" applicable to this article?

Thanks for your feedback.
Cell binding
Is the Subject Area "Cell binding" applicable to this article?

Thanks for your feedback.
Weill-Marchesani syndrome
Is the Subject Area "Weill-Marchesani syndrome" applicable to this article?

Thanks for your feedback.