About the Authors

Seraina Cooksley-Decasper

Affiliations Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland, Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland

Hans Reiser

Affiliations Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland, Competence Center for Systems Physiology and Metabolic Diseases (CC-SPMD), Zurich, Switzerland

Daniela S. Thommen

Affiliation Department of Biomedicine, University Hospital Basel, Basel, Switzerland

Barbara Biedermann

Affiliation Department of Biomedicine, University Hospital Basel, Basel, Switzerland

Michel Neidhart

Affiliations Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Institute for Experimental Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland

Joanna Gawinecka

Affiliation Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland

Gieri Cathomas

Affiliation Cantonal Institute for Pathology, Liestal, Switzerland

Fabian C. Franzeck

Affiliation Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Christophe Wyss

Affiliation Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Roland Klingenberg

Affiliation Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Paolo Nanni

Affiliation Functional Genomics Center Zurich (FGCZ), Zurich, Switzerland

Bernd Roschitzki

Affiliation Functional Genomics Center Zurich (FGCZ), Zurich, Switzerland

Christian Matter

Affiliations Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Petra Wolint

Affiliation Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland

Maximilian Y. Emmert

Affiliation Department of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland

Marc Husmann

Affiliation Department of Angiology, University Hospital Zurich, Zurich, Switzerland

Beatrice Amann-Vesti

Affiliation Department of Angiology, University Hospital Zurich, Zurich, Switzerland

Wilibald Maier

Affiliations Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Steffen Gay

Affiliations Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Institute for Experimental Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland

Thomas F. Lüscher

Affiliations Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Department of Cardiology and Cardiovascular Physiology, University Hospital Zurich, Zurich, Switzerland

Arnold von Eckardstein

Contributed equally to this work with: Arnold von Eckardstein, Danielle Hof

Harnold.voneckardstein@usz.ch

Affiliations Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland, Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland, Competence Center for Systems Physiology and Metabolic Diseases (CC-SPMD), Zurich, Switzerland

Danielle Hof

Contributed equally to this work with: Arnold von Eckardstein, Danielle Hof

Affiliation Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland

Competing Interests

Seraina Cooksley-Decasper, Danielle Hof and Arnold von Eckardstein hold a patent on JUP as a biomarker of cardiovascular disease (EP11162136). No further declarations are to be made. The authors confirm that their patent does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The patent was registered as a European patent at the European Patent Office.

Author Contributions

Conceived and designed the experiments: SCD AvE DH. Performed the experiments: SCD HR MN JG GC PN BR. Analyzed the data: SCD HR BB PN BR AvE DH. Contributed reagents/materials/analysis tools: DST BB FCF CW RK PW MYE MH BAV WM. Wrote the paper: SCD DH AvE. Was involved in critical revision of the manuscript: JG SG CM TFL.