About the Authors

Johanna S. Blees

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Heidi R. Bokesch

Affiliations Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Daniela Rübsamen

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Kathrin Schulz

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Larissa Milke

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Magdalena M. Bajer

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Kirk R. Gustafson

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Curtis J. Henrich

Affiliations Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

James B. McMahon

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Nancy H. Colburn

Affiliation Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Tobias Schmid

Contributed equally to this work with: Tobias Schmid, Bernhard Brüne

T.Schmid@biochem.uni-frankfurt.de

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Bernhard Brüne

Contributed equally to this work with: Tobias Schmid, Bernhard Brüne

Affiliation Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany

Competing Interests

Two of the authors (HRB, CJH) are employed by SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, which is a U.S. Government contractor, thus funding comes from the U.S. Government. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JSB KRG CJH TS. Performed the experiments: JSB HRB MMB TS. Analyzed the data: JSB KRG DR KS LM MMB TS BB. Contributed reagents/materials/analysis tools: KRG CJH NHC JBM BB. Wrote the paper: JSB HRB KRG CJH TS BB.