About the Authors

Hongying Yang

Hongying.2.yang@gsk.com

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Wei Zhang

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China

Heng Pan

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China

Heidi G. Feldser

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Elden Lainez

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Christine Miller

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Stewart Leung

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China

Zhong Zhong

Affiliation GlaxoSmithKline R&D China, Shanghai, People’s Republic of China

Huizhen Zhao

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Sharon Sweitzer

Affiliation GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Thomas Considine

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Thomas Riera

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Vipin Suri

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Brian White

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

James L. Ellis

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

George P. Vlasuk

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Christine Loh

Affiliation Sirtris, a GSK Company, Cambridge, Massachusetts, United States of America

Competing Interests

All authors are employed by GlaxoSmithKline. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HY WZ HP HGF CM SL ZZ VS CL. Performed the experiments: HY HGF EL CM TC TR CL. Analyzed the data: HY HGF EL CM TC TR CL. Contributed reagents/materials/analysis tools: BW HZ SS. Wrote the paper: HY CL. Critically revised the manuscript: JLE GPV.