About the Authors

Jatinder K. Juss

Affiliations Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom, Inositide Laboratory, The Babraham Institute, Cambridge, United Kingdom

Richard P. Hayhoe

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom

Charles E. Owen

Affiliation Novartis, Horsham Research Centre, Horsham, United Kingdom

Ian Bruce

Affiliation Novartis, Horsham Research Centre, Horsham, United Kingdom

Sarah R. Walmsley

Affiliation Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, United Kingdom

Andrew S. Cowburn

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom

Suhasini Kulkarni

Affiliation Inositide Laboratory, The Babraham Institute, Cambridge, United Kingdom

Keith B. Boyle

Affiliation Inositide Laboratory, The Babraham Institute, Cambridge, United Kingdom

Len Stephens

Contributed equally to this work with: Len Stephens, Phillip T. Hawkins, Edwin R. Chilvers, Alison M. Condliffe

Affiliation Inositide Laboratory, The Babraham Institute, Cambridge, United Kingdom

Phillip T. Hawkins

Contributed equally to this work with: Len Stephens, Phillip T. Hawkins, Edwin R. Chilvers, Alison M. Condliffe

Affiliation Inositide Laboratory, The Babraham Institute, Cambridge, United Kingdom

Edwin R. Chilvers

Contributed equally to this work with: Len Stephens, Phillip T. Hawkins, Edwin R. Chilvers, Alison M. Condliffe

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom

Alison M. Condliffe

Contributed equally to this work with: Len Stephens, Phillip T. Hawkins, Edwin R. Chilvers, Alison M. Condliffe

amc46@medschl.cam.ac.uk

Affiliation Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom

Competing Interests

Ian Bruce and Charles Owen are employed by Novartis. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ERC AMC PTH CEO LS SK KB. Performed the experiments: JKJ RPH. Analyzed the data: JKJ RPH. Contributed reagents/materials/analysis tools: ISB. Wrote the paper: AMC ERC PTH LS. Developed novel experimental methodologies: SRW ASC.