Differential Dependencies of Monocytes and Neutrophils on Dectin-1, Dectin-2 and Complement for the Recognition of Fungal Particles in Inflammation

Jacqueline U. McDonald; Marcela Rosas; Gordon D. Brown; Simon A. Jones; Philip R. Taylor

doi:10.1371/journal.pone.0045781

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Open Access

Peer-reviewed

Research Article

Differential Dependencies of Monocytes and Neutrophils on Dectin-1, Dectin-2 and Complement for the Recognition of Fungal Particles in Inflammation

Jacqueline U. McDonald,

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
⨯
Marcela Rosas,

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
⨯
Gordon D. Brown,

Affiliation Section of Infection and Immunity, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
⨯
Simon A. Jones,

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
⨯
Philip R. Taylor

* E-mail: TaylorPR@cf.ac.uk

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
⨯

Differential Dependencies of Monocytes and Neutrophils on Dectin-1, Dectin-2 and Complement for the Recognition of Fungal Particles in Inflammation

Jacqueline U. McDonald,
Marcela Rosas,
Gordon D. Brown,
Simon A. Jones,
Philip R. Taylor

Published: September 26, 2012
https://doi.org/10.1371/journal.pone.0045781

About the Authors

Jacqueline U. McDonald

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

Marcela Rosas

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

Gordon D. Brown

Affiliation Section of Infection and Immunity, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

Simon A. Jones

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

Philip R. Taylor

* E-mail: TaylorPR@cf.ac.uk

Affiliation Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JUM MR SAJ PRT. Performed the experiments: JUM MR PRT. Analyzed the data: JUM MR GDB SAJ PRT. Contributed reagents/materials/analysis tools: GDB. Wrote the paper: PRT.

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Inflammation
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Neutrophils
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Monocytes
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Candida albicans
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Opsonization
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Complement system
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Peritonitis
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Fungal pathogens
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