Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

Vincent A. Carlier; Luc VanderElst; Wim Janssens; Marc G. Jacquemin; Jean-Marie R. Saint-Remy

doi:10.1371/journal.pone.0045366

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Open Access

Peer-reviewed

Research Article

Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

Vincent A. Carlier ,

Contributed equally to this work with: Vincent A. Carlier, Luc VanderElst
⨯
Luc VanderElst ,

Contributed equally to this work with: Vincent A. Carlier, Luc VanderElst
⨯
Wim Janssens,
Marc G. Jacquemin,
Jean-Marie R. Saint-Remy

* E-mail: jeanmarie.saint-remy@med.kuleuven.ac.be

Affiliation Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
⨯

Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

Vincent A. Carlier,
Luc VanderElst,
Wim Janssens,
Marc G. Jacquemin,
Jean-Marie R. Saint-Remy

Published: October 9, 2012
https://doi.org/10.1371/journal.pone.0045366

About the Authors

Vincent A. Carlier

Contributed equally to this work with: Vincent A. Carlier, Luc VanderElst

Luc VanderElst

Contributed equally to this work with: Vincent A. Carlier, Luc VanderElst

Wim Janssens

Marc G. Jacquemin

Jean-Marie R. Saint-Remy

* E-mail: jeanmarie.saint-remy@med.kuleuven.ac.be

Affiliation Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VC LV JMSR. Performed the experiments: VC. Analyzed the data: VC LV JMSR. Wrote the paper: JMSR VC. Revised the manuscript: WJ MJ.

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T cells
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B cells
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Antigen-presenting cells
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Apoptosis
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Cell staining
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Synapses
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T helper cells
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Major histocompatibility complex
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