Cross Tissue Trait-Pathway Network Reveals the Importance of Oxidative Stress and Inflammation Pathways in Obesity-Induced Diabetes in Mouse

Shouguo Gao; Herbert Keith Roberts; Xujing Wang

doi:10.1371/journal.pone.0044544

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Open Access

Peer-reviewed

Research Article

Cross Tissue Trait-Pathway Network Reveals the Importance of Oxidative Stress and Inflammation Pathways in Obesity-Induced Diabetes in Mouse

Shouguo Gao,

Affiliations Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, The Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Herbert Keith Roberts,

Affiliation Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Xujing Wang

* E-mail: xujingw@uab.edu

Affiliations Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, The Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Cross Tissue Trait-Pathway Network Reveals the Importance of Oxidative Stress and Inflammation Pathways in Obesity-Induced Diabetes in Mouse

Shouguo Gao,
Herbert Keith Roberts,
Xujing Wang

Published: September 17, 2012
https://doi.org/10.1371/journal.pone.0044544

About the Authors

Shouguo Gao

Affiliations Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, The Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Herbert Keith Roberts

Affiliation Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Xujing Wang

* E-mail: xujingw@uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SG XW. Performed the experiments: SG HKR XW. Analyzed the data: SG HKR XW. Contributed reagents/materials/analysis tools: SG XW. Wrote the paper: SG XW.

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Obesity
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Metabolic pathways
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Diabetes mellitus
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Cell metabolism
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Insulin
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Hypothalamus
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Network analysis
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Genetic networks
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