An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack

Tobias Jahn; Martin Zuther; Björn Friedrichs; Claudia Heuser; Stefan Guhlke; Hinrich Abken; Andreas A. Hombach

doi:10.1371/journal.pone.0044482

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Open Access

Peer-reviewed

Research Article

An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack

Tobias Jahn ,

Contributed equally to this work with: Tobias Jahn, Martin Zuther
⨯
Martin Zuther ,

Contributed equally to this work with: Tobias Jahn, Martin Zuther
⨯
Björn Friedrichs,
Claudia Heuser,
Stefan Guhlke,
Hinrich Abken,
Andreas A. Hombach

*E-mail:andreas.hombach@uk-koeln.de

Affiliation Department I of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
⨯

An Il12-Il2-Antibody Fusion Protein Targeting Hodgkin's Lymphoma Cells Potentiates Activation Of Nk And T Cells For An Anti-Tumor Attack

Tobias Jahn,
Martin Zuther,
Björn Friedrichs,
Claudia Heuser,
Stefan Guhlke,
Hinrich Abken,
Andreas A. Hombach

Published: September 18, 2012
https://doi.org/10.1371/journal.pone.0044482

About the Authors

Tobias Jahn

Contributed equally to this work with: Tobias Jahn, Martin Zuther

Martin Zuther

Contributed equally to this work with: Tobias Jahn, Martin Zuther

Björn Friedrichs

Claudia Heuser

Stefan Guhlke

Hinrich Abken

Andreas A. Hombach

*E-mail:andreas.hombach@uk-koeln.de

Affiliation Department I of Internal Medicine and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAH HA SG. Performed the experiments: TJ MZ BF CH SG AAH. Analyzed the data: TJ MZ BF CH SG AAH. Wrote the paper: HA AAH.

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Cell fusion
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Cytokines
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T cells
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NK cells
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Cancers and neoplasms
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Hodgkin lymphoma
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Enzyme-linked immunoassays
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Hybridomas
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