About the Authors

Michael G. Zager

michael.zager@pfizer.com

Affiliation Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer, Inc., San Diego, California, United States of America

Hugh A. Barton

Affiliation Pharmacokinetics, Dynamics and Metabolism, Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut, United States of America

Competing Interests

MGZ is employed at Pfizer Worldwide Research and Development, San Diego, CA, and HAB is employed at Pfizer Worldwide Research and Development, Groton, CT. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Analyzed the data: MGZ HAB. Wrote the paper: MGZ HAB. Developed model code: MGZ. Ran simulations: MGZ.