About the Authors
- Herman A. van Wietmarschen
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Contributed equally to this work with: Herman A. van Wietmarschen, Weidong Dai
* E-mail: h.vanwietmarschen@lacdr.leidenuniv.nl (HvW); xugw@dicp.ac.cn (GX)
Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands
- Weidong Dai
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Contributed equally to this work with: Herman A. van Wietmarschen, Weidong Dai
Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
- Anita J. van der Kooij
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Affiliation Mathematical Institute, Leiden University, Leiden, The Netherlands
- Theo H. Reijmers
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Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands
- Yan Schroën
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Affiliations Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, Oxrider, Education and Research, Nieuwegein, The Netherlands
- Mei Wang
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Affiliations Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Utrechtseweg, Zeist, The Netherlands
- Zhiliang Xu
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Affiliation College of Life Science Company Limited, Hangzhou, China
- Xinchang Wang
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Affiliation Zhejiang Xinhua hospital Rheumatology and Immunology Department, HangZhou, China
- Hongwei Kong
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Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
- Guowang Xu
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* E-mail: h.vanwietmarschen@lacdr.leidenuniv.nl (HvW); xugw@dicp.ac.cn (GX)
Affiliation CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
- Thomas Hankemeier
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Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands
- Jacqueline J. Meulman
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Affiliation Mathematical Institute, Leiden University, Leiden, The Netherlands
- Jan van der Greef
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Affiliations Division of Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands, Sino-Dutch centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Utrechtseweg, Zeist, The Netherlands, TNO Netherlands Organization for Applied Scientific Research, TNO Pharma, Zeist, The Netherlands
Competing Interests
Dr. Mei Wang is employed by SUBiomedicine, Dr. Zhiliang Xu is employed by the College of Life Science Company Ltd. and Prof. Jan van der Greef is employed by TNO. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: HAW JG THR JJM. Performed the experiments: XW WD. Analyzed the data: HAW THR YS JJM AJK. Contributed reagents/materials/analysis tools: ZX HK TH XW GX MW. Wrote the paper: HAW WD. Conducted patient recruitment: XW ZX GX HK MW.