TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells

Pingde Zhang; Stephanie Si Liu; Hextan Yuen Sheung Ngan

doi:10.1371/journal.pone.0042985

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Open Access

Peer-reviewed

Research Article

TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells

Pingde Zhang,

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
⨯
Stephanie Si Liu,

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
⨯
Hextan Yuen Sheung Ngan

* E-mail: gyonc@hku.hk

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China
⨯

TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells

Pingde Zhang,
Stephanie Si Liu,
Hextan Yuen Sheung Ngan

Published: August 10, 2012
https://doi.org/10.1371/journal.pone.0042985

About the Authors

Pingde Zhang

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China

Stephanie Si Liu

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China

Hextan Yuen Sheung Ngan

* E-mail: gyonc@hku.hk

Affiliation Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PZ SSL HYN. Performed the experiments: PZ. Analyzed the data: PZ SSL HYN. Contributed reagents/materials/analysis tools: SSL HYN. Wrote the paper: PZ SSL HYN.

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Apoptosis
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Ovarian cancer
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c-Jun N-terminal kinase signaling cascade
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Cancer treatment
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Small interfering RNA
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Cellular stress responses
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DNA damage
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Phosphorylation
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