About the Authors

Gilles Capellier

gilles.capellier@univ-fcomte.fr

Affiliations Réanimation médicale adulte, Pôle Urgences-SAMU-Réanimation CHU, Besancon, Doubs, France, EA 3920, Univ-Fcomte, Besancon, Doubs, France

Hélène Mockly

Affiliation Pôle pharmaceutique, CHU, Besancon, Doubs, France

Claire Charpentier

Affiliation Service de réanimation chirurgicale adulte, Hôpital Central, Nancy, Lorraine, France

Djillali Annane

Affiliation Service médico-chirurgical adulte, CHU Raymond Poincaré - Assistance Publique Hôpitaux de Paris, Garches, Ile de France, France

Gilles Blasco

Affiliation Service de réanimation chirurgicale adulte, CHU, Besancon, Doubs, France

Thibault Desmettre

Affiliations Réanimation médicale adulte, Pôle Urgences-SAMU-Réanimation CHU, Besancon, Doubs, France, EA 3920, Univ-Fcomte, Besancon, Doubs, France

Antoine Roch

Affiliations Service de Réanimation médicale - URMITE, Assistance Publique Hôpitaux de Marseille, Marseille, Bouches du Rhône, France, CNRS-UMR 6236, Université de la Méditerranée Aix-Marseille II, Marseille, Bouches du Rhône, France

Christophe Faisy

Affiliation Service de réanimation médicale adulte, HEGP-Assistance Publique Hôpitaux de Paris, Paris, Ile de France, France

Joel Cousson

Affiliation Service de réanimation polyvalente adulte, Hôpital Robert Debré, Reims, Champagne, France

Samuel Limat

Affiliations Pôle pharmaceutique, CHU, Besancon, Doubs, France, EA 4267, Univ-Fcomte, Besancon, Doubs, France

Mariette Mercier

Affiliations Laboratoire de Biostatistique, CHU, Besancon, Doubs, France, EA3181, Univ-Fcomte, Besancon, Doubs, France

Laurent Papazian

Affiliations Service de Réanimation médicale - URMITE, Assistance Publique Hôpitaux de Marseille, Marseille, Bouches du Rhône, France, CNRS-UMR 6236, Université de la Méditerranée Aix-Marseille II, Marseille, Bouches du Rhône, France

Competing Interests

The authors have read the journal's policy and have the following conflicts: Glaxo and Beecham Laboratory were part funders of this study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: GC HM SL MM LP. Performed the experiments: GC DA TD JC CC LP CF GB AR. Analyzed the data: HM MM SL GC. Contributed reagents/materials/analysis tools: HM MM SL. Wrote the paper: GC HM LP MM DA.