Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus

Daohong Chen; Xiaolei Liu; Weiping Zhang; Yuguang Shi

doi:10.1371/journal.pone.0040764

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Open Access

Peer-reviewed

Research Article

Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus

Daohong Chen ,

Contributed equally to this work with: Daohong Chen, Xiaolei Liu

Affiliation Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
⨯
Xiaolei Liu ,

Contributed equally to this work with: Daohong Chen, Xiaolei Liu

Affiliations Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Pharmacology, School of Pharmaceutical Sciences Central South University, Changsha, China
⨯
Weiping Zhang,

Affiliation Department of Pathophysiology, Second Military Medical University Shanghai, China
⨯
Yuguang Shi

* E-mail: yus11@psu.edu

Affiliation Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
⨯

Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus

Daohong Chen,
Xiaolei Liu,
Weiping Zhang,
Yuguang Shi

Published: July 16, 2012
https://doi.org/10.1371/journal.pone.0040764

About the Authors

Daohong Chen

Contributed equally to this work with: Daohong Chen, Xiaolei Liu

Affiliation Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

Xiaolei Liu

Contributed equally to this work with: Daohong Chen, Xiaolei Liu

Affiliations Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Pharmacology, School of Pharmaceutical Sciences Central South University, Changsha, China

Weiping Zhang

Affiliation Department of Pathophysiology, Second Military Medical University Shanghai, China

Yuguang Shi

* E-mail: yus11@psu.edu

Affiliation Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WZ YS. Performed the experiments: DC XL. Analyzed the data: DC XL YS. Contributed reagents/materials/analysis tools: WZ. Wrote the paper: DC YS.

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Obesity
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Genetically modified animals
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Hypothalamus
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Adipose tissue
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Bioenergetics
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Mouse models
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Body weight
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Phosphorylation
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