Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-κB in R-HepG2 Cell Line

Jianguo Sun; Chilam Au Yeung; Ngai Na Co; Tsun Yee Tsang; Esmond Yau; Kewang Luo; Ping Wu; Judy Chan Yuet Wa; Kwok-Pui Fung; Tim-Tak Kwok; Feiyan Liu

doi:10.1371/journal.pone.0040720

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Open Access

Peer-reviewed

Research Article

Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-κB in R-HepG2 Cell Line

Jianguo Sun,

Affiliations Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, People's Republic of China, Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China
⨯
Chilam Au Yeung,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Ngai Na Co,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Tsun Yee Tsang,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Esmond Yau,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Kewang Luo,

Affiliations Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, People's Republic of China, Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China
⨯
Ping Wu,

Affiliations Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, People's Republic of China, Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China
⨯
Judy Chan Yuet Wa,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Kwok-Pui Fung,

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Tim-Tak Kwok ,

* E-mail: liuf64@zju.edu.cn (FL); tkwok2020@yahoo.com.hk (TTK)

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China
⨯
Feiyan Liu

* E-mail: liuf64@zju.edu.cn (FL); tkwok2020@yahoo.com.hk (TTK)

Affiliations Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, People's Republic of China, Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China
⨯

Clitocine Reversal of P-Glycoprotein Associated Multi-Drug Resistance through Down-Regulation of Transcription Factor NF-κB in R-HepG2 Cell Line

Jianguo Sun,
Chilam Au Yeung,
Ngai Na Co,
Tsun Yee Tsang,
Esmond Yau,
Kewang Luo,
Ping Wu,
Judy Chan Yuet Wa,
Kwok-Pui Fung,
Tim-Tak Kwok

Published: August 22, 2012
https://doi.org/10.1371/journal.pone.0040720

About the Authors

Jianguo Sun

Affiliations Zhejiang University, Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zijinggang Campus, Hangzhou, People's Republic of China, Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China

Chilam Au Yeung

Affiliations Zhejiang University, Joint centre of Zhejiang University and The Chinese University of Hong Kong on Natural Products and Toxicology Research, Zijinggang Campus, Hangzhou , People's Republic of China, School of Biomedical Sciences (SBS), The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China

Ngai Na Co

Tsun Yee Tsang

Esmond Yau

Kewang Luo

Ping Wu

Judy Chan Yuet Wa

Kwok-Pui Fung

Tim-Tak Kwok

* E-mail: liuf64@zju.edu.cn (FL); tkwok2020@yahoo.com.hk (TTK)

Feiyan Liu

* E-mail: liuf64@zju.edu.cn (FL); tkwok2020@yahoo.com.hk (TTK)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FL TTK PW KPF. Performed the experiments: JS CAY KL JCYW. Analyzed the data: NNC TYT. Contributed reagents/materials/analysis tools: EY. Wrote the paper: FL TTK.

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Transcription factors
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Cancer treatment
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Hepatocellular carcinoma
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Polymerase chain reaction
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