About the Authors

Alyson M. Auliff

Affiliations Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Enoggera, Queensland, Australia, School of Population Health, University of Queensland, Brisbane, Queensland, Australia

Bharath Balu

Current address: Tropical Disease Research Program, Center for Infectious Disease and Biodefense Research, SRI International, Harrisonburg, Virginia, United States of America

Affiliation Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Nanhua Chen

Affiliation Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Enoggera, Queensland, Australia

Michael T. O’Neil

Affiliation Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

Qin Cheng

jadams3@health.usf.edu (JHA); qin.cheng@defence.gov.au (QC)

Affiliations Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Enoggera, Queensland, Australia, School of Population Health, University of Queensland, Brisbane, Queensland, Australia

John H. Adams

jadams3@health.usf.edu (JHA); qin.cheng@defence.gov.au (QC)

Affiliation Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Competing Interests

While Jacobus Pharmaceutical Company (Princeton, New Jersey) kindly supplied the antimalarial compounds WR99210 and JPC-2067 and Dr. Don Gardiner, QIMR (Brisbane, Australia) kindly supplied Rex 1 antibody, the authors do not have commercial or other association that might pose a conflict. This does not alter the authors’ adherance to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AMA QC JHA. Performed the experiments: AMA BB. Analyzed the data: AMA BB MTO NC QC. Contributed reagents/materials/analysis tools: QC JHC. Wrote the paper: AMA.