About the Authors

Colin D. Chue

Affiliations School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Department of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Nadezhda A. Wall

Affiliation School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

Nicola J. Crabtree

Affiliation Department of Endocrinology, Birmingham Children's Hospital, Birmingham, United Kingdom

Daniel Zehnder

Affiliation Clinical Sciences Research Institute, University of Warwick, Coventry, United Kingdom

William E. Moody

Affiliations School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Department of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Nicola C. Edwards

Affiliations School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Department of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Richard P. Steeds

Affiliation Department of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Jonathan N. Townend

Affiliation Department of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Charles J. Ferro

charles.ferro@uhb.nhs.uk

Affiliation Department of Nephrology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom

Competing Interests

The authors have read the journal's policy and have the following conflicts: CJF, JNT, RPS and CDC are recipients of an unrestricted educational grant from Genzyme Corporation. CJF and CDC have received lecture fees and advisory board fees from Genzyme Corporation. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CJF JNT RPS CDC. Performed the experiments: CDC NAW WEM NCE RPS. Analyzed the data: CDC NAW NJC DZ RPS. Contributed reagents/materials/analysis tools: NJC DZ RPS. Wrote the paper: CDC CJF NAW WEM NCE JNT RPS.