About the Authors

Nataliya Kotelevets

Affiliation Institute of Pharmacology, University of Bern, Bern, Switzerland

Doriano Fabbro

Affiliation Novartis Pharma AG, NIBR Basel, Switzerland

Andrea Huwiler

Affiliations Institute of Pharmacology, University of Bern, Bern, Switzerland, Pharmazentrum Frankfurt/ZAFES, University Hospital Frankfurt, Frankfurt am Main, Germany

Uwe Zangemeister-Wittke

uwe.zangemeister@pki.unibe.ch

Affiliations Institute of Pharmacology, University of Bern, Bern, Switzerland, Institute of Biochemistry, University of Zürich, Zürich, Switzerland

Competing Interests

Author D. Fabbro is employed at Novartis Pharma AG. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NK DF AH UZW. Performed the experiments: NK. Analyzed the data: NK AH UZW. Contributed reagents/materials/analysis tools: DF AH UZW. Wrote the paper: NK DF AH UZW.