About the Authors

William S. Bradham

william.bradham@vanderbilt.edu

Affiliation Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Aihua Bian

Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Annette Oeser

Affiliation Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Tebeb Gebretsadik

Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Ayumi Shintani

Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Joseph Solus

Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Joel Estis

Affiliation Singulex Inc., Alameda, California, United States of America

Quynh Anh Lu

Affiliation Singulex Inc., Alameda, California, United States of America

John Todd

Affiliation Singulex Inc., Alameda, California, United States of America

Paolo Raggi

Affiliation Division of Cardiology, Emory University, Atlanta, Georgia, United States of America

C. Michael Stein

Affiliation Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Competing Interests

Joel Estis, Quynh Anh Lu, and John Todd are employees and shareholders in Singulex Corp., developed the high sensitivity troponin assay, and performed this analysis for the study. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WSB CMS. Performed the experiments: WSB AO JS JE QAL JT. Analyzed the data: WSB CMS AB TG AS JS PR. Contributed reagents/materials/analysis tools: JE QAL JT. Wrote the paper: WSB CMS.