About the Authors

Helene C. D. Østerholt

Contributed equally to this work with: Helene C. D. Østerholt, Ingrid Dannevig, Myra H. Wyckoff, Jie Liao

Affiliations Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Institute for Surgical Research, Oslo University Hospital – Rikshospitalet, Oslo, Norway

Ingrid Dannevig

Contributed equally to this work with: Helene C. D. Østerholt, Ingrid Dannevig, Myra H. Wyckoff, Jie Liao

Affiliations Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Institute for Surgical Research, Oslo University Hospital – Rikshospitalet, Oslo, Norway

Myra H. Wyckoff

Contributed equally to this work with: Helene C. D. Østerholt, Ingrid Dannevig, Myra H. Wyckoff, Jie Liao

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Jie Liao

Contributed equally to this work with: Helene C. D. Østerholt, Ingrid Dannevig, Myra H. Wyckoff, Jie Liao

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Yucel Akgul

Affiliation Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Mrithyunjay Ramgopal

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Dan S. Mija

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Naeun Cheong

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Christopher Longoria

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Mala Mahendroo

Affiliation Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Britt Nakstad

Affiliations Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Ola D. Saugstad

Affiliation Department of Pediatric Research, Oslo University Hospital – Rikshospitalet, Oslo, Norway

Rashmin C. Savani

rashmin.savani@utsouthwestern.edu

Affiliation Divisions of Pulmonary and Vascular Biology and Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Competing Interests

For this study a research grant award to MHW and RCS came from Ikaria Therapeutics. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: HCDO ID MHW BN ODS RCS. Performed the experiments: HCDO ID MHW JL YA MR DSM NC CL. Analyzed the data: HCDO ID MHW JL YA MR DSM NC CL MM BN ODS RCS. Contributed reagents/materials/analysis tools: MM ODS RCS. Wrote the paper: HCDO ID MHW ODS RCS.