About the Authors
- Masayuki Takahashi
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Contributed equally to this work with: Masayuki Takahashi, Reyad A. Elbarbary
Affiliation Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
- Reyad A. Elbarbary
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Contributed equally to this work with: Masayuki Takahashi, Reyad A. Elbarbary
Affiliation Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
- Mayumi Abe
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Affiliation Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
- Mari Sato
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Affiliation Department of Biochemistry and Molecular Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
- Tetsuo Yoshida
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Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Company Limited, Machida, Japan
- Yoji Yamada
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Affiliation Biologics Research Laboratories, Kyowa Hakko Kirin Company Limited, Machida, Japan
- Masato Tamura
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Affiliation Department of Biochemistry and Molecular Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
- Masayuki Nashimoto
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* E-mail: mnashimoto@nupals.ac.jp
Affiliation Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Competing Interests
The authors have read the journal’s policy and have the following conflicts: The authors TY and YY are employees of Kyowa Hakko Kirin. Niigata University of Pharmacy and Applied Life Sciences has a pending patent application on the miRNA-targeting sgRNAs. The authors TY, YY and MN are named as inventors in this application. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: RAE MN. Performed the experiments: M. Takahashi RAE MA MS M. Tamura. Analyzed the data: M. Takahashi RAE TY YY M. Tamura MN. Wrote the paper: MN.