About the Authors

Alessandro Tozzi

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy

Antonio de Iure

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy

Valentina Marsili

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy

Rosaria Romano

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy

Michela Tantucci

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy

Massimiliano Di Filippo

Affiliation Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy

Cinzia Costa

Affiliation Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy

Francesco Napolitano

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy

Nicola Biagio Mercuri

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy

Franco Borsini

Affiliation Sigma - tau Industrie Riunite, Pomezia, Italy

Carmen Giampà

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy

Francesca Romana Fusco

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy

Barbara Picconi

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy

Alessandro Usiello

Affiliations CEINGE - Biotecnologie Avanzate, Naples, Italy, Second University of Naples (SUN), Naples, Italy

Paolo Calabresi

calabre@unipg.it

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy

Competing Interests

Dr. Calabresi serves as an editorial board member of Lancet Neurology, the Journal of Neuroscience, Movement Disorders and Synapse; receives research support from Bayer Schering, Biogen, Boehringer Ingelheim, Eisai, Novartis, Lundbeck, Sanofi-Aventis, Sigma-Tau, and UCB Pharma; and from Ricerca Corrente IRCCS, Ricerca Finalizzata IRCCS [European Community Grants SYNSCAFF and REPLACES], the Italian Minister of Health and AIFA (Agenzia Italiana del Farmaco). Dr. Franco Borsini is employed by Sigma-tau Industrie Riunite, Pomezia, Italy. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials. All other authors reported no biomedical financial interests or potential conflicts of interest.

Author Contributions

Conceived and designed the experiments: AT AU PC. Performed the experiments: AT AD VM RR CG. Analyzed the data: AT AD VM RR CG CC FRF. Wrote the paper: AT MD NBM FB BP MT FN AU PC.