A Coevolutionary Residue Network at the Site of a Functionally Important Conformational Change in a Phosphohexomutase Enzyme Family

Yingying Lee; Jacob Mick; Cristina Furdui; Lesa J. Beamer

doi:10.1371/journal.pone.0038114

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Open Access

Peer-reviewed

Research Article

A Coevolutionary Residue Network at the Site of a Functionally Important Conformational Change in a Phosphohexomutase Enzyme Family

Yingying Lee ,

Contributed equally to this work with: Yingying Lee, Jacob Mick

Affiliation Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America
⨯
Jacob Mick ,

Contributed equally to this work with: Yingying Lee, Jacob Mick

Affiliation Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America
⨯
Cristina Furdui,

Affiliation Department of Internal Medicine, Wake Forest University Health Sciences Winston-Salem, North Carolina, United States of America
⨯
Lesa J. Beamer

* E-mail: beamerl@missouri.edu

Affiliations Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America, Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America
⨯

A Coevolutionary Residue Network at the Site of a Functionally Important Conformational Change in a Phosphohexomutase Enzyme Family

Yingying Lee,
Jacob Mick,
Cristina Furdui,
Lesa J. Beamer

Published: June 7, 2012
https://doi.org/10.1371/journal.pone.0038114

About the Authors

Yingying Lee

Contributed equally to this work with: Yingying Lee, Jacob Mick

Affiliation Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America

Jacob Mick

Contributed equally to this work with: Yingying Lee, Jacob Mick

Affiliation Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America

Cristina Furdui

Affiliation Department of Internal Medicine, Wake Forest University Health Sciences Winston-Salem, North Carolina, United States of America

Lesa J. Beamer

* E-mail: beamerl@missouri.edu

Affiliations Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America, Department of Biochemistry, University of Missouri, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YL JM LJB. Performed the experiments: YL JM. Analyzed the data: CF LJB. Wrote the paper: LJB.

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Pseudomonas aeruginosa
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Sequence alignment
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Coevolution
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Glucose
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Multiple alignment calculation
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Enzymes
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