Low Dose Vaccination with Attenuated Francisella tularensis Strain SchuS4 Mutants Protects against Tularemia Independent of the Route of Vaccination

Dedeke Rockx-Brouwer; Audrey Chong; Tara D. Wehrly; Robert Child; Deborah D. Crane; Jean Celli; Catharine M. Bosio

doi:10.1371/journal.pone.0037752

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Peer-reviewed

Research Article

Low Dose Vaccination with Attenuated Francisella tularensis Strain SchuS4 Mutants Protects against Tularemia Independent of the Route of Vaccination

Dedeke Rockx-Brouwer,

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Audrey Chong,

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Tara D. Wehrly,

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Robert Child,

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Deborah D. Crane,

Affiliation Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Jean Celli ,

Contributed equally to this work with: Jean Celli, Catharine M. Bosio

* E-mail: jcelli@niaid.nih.gov (JC); bosioc@niaid.nih.gov (CMB)

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯
Catharine M. Bosio

Contributed equally to this work with: Jean Celli, Catharine M. Bosio

* E-mail: jcelli@niaid.nih.gov (JC); bosioc@niaid.nih.gov (CMB)

Affiliation Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America
⨯

Low Dose Vaccination with Attenuated Francisella tularensis Strain SchuS4 Mutants Protects against Tularemia Independent of the Route of Vaccination

Dedeke Rockx-Brouwer,
Audrey Chong,
Tara D. Wehrly,
Robert Child,
Deborah D. Crane,
Jean Celli,
Catharine M. Bosio

Published: May 25, 2012
https://doi.org/10.1371/journal.pone.0037752

About the Authors

Dedeke Rockx-Brouwer

Affiliation Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America

Audrey Chong

Tara D. Wehrly

Robert Child

Deborah D. Crane

Affiliation Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, Montana, United States of America

Jean Celli

Contributed equally to this work with: Jean Celli, Catharine M. Bosio

* E-mail: jcelli@niaid.nih.gov (JC); bosioc@niaid.nih.gov (CMB)

Catharine M. Bosio

Contributed equally to this work with: Jean Celli, Catharine M. Bosio

* E-mail: jcelli@niaid.nih.gov (JC); bosioc@niaid.nih.gov (CMB)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JC CMB. Performed the experiments: DRB AC TW RC DDC CMB. Analyzed the data: DRB AC JC CMB. Contributed reagents/materials/analysis tools: JC CMB. Wrote the paper: JC CMB.

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Francisella tularensis
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Vaccination and immunization
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Tularemia
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Attenuated vaccines
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Macrophages
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Deletion mutagenesis
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Mutant strains
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Vaccines
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