Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

Zhiyong Deng; Guangchao Sui; Paulo Mottin Rosa; Weiling Zhao

doi:10.1371/journal.pone.0036739

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Open Access

Peer-reviewed

Research Article

Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

Zhiyong Deng,

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Guangchao Sui,

Affiliation Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Paulo Mottin Rosa,

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Weiling Zhao

* E-mail: wzhao@wakehealth.edu

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
⨯

Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells

Zhiyong Deng,
Guangchao Sui,
Paulo Mottin Rosa,
Weiling Zhao

Published: May 14, 2012
https://doi.org/10.1371/journal.pone.0036739

About the Authors

Zhiyong Deng

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Guangchao Sui

Affiliation Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Paulo Mottin Rosa

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Weiling Zhao

* E-mail: wzhao@wakehealth.edu

Affiliation Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZD WZ GS. Performed the experiments: ZD WZ PMR. Analyzed the data: ZD WZ. Wrote the paper: ZD WZ.

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MAPK signaling cascades
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DNA-binding proteins
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c-Jun N-terminal kinase signaling cascade
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Microglial cells
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Phosphorylation
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ERK signaling cascade
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Inflammation
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Radiation therapy
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