About the Authors

Ji-jing Pang

Contributed equally to this work with: Ji-jing Pang, Wen-Tao Deng

jpang@ufl.edu

Affiliations Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America, Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, China

Wen-Tao Deng

Contributed equally to this work with: Ji-jing Pang, Wen-Tao Deng

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Xufeng Dai

Affiliations Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America, Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou, China

Bo Lei

Affiliation Chongqing Key Laboratory of Ophthalmology, Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Drew Everhart

Affiliation Ophthalmology, SUNY Upstate Medical University, Syracuse, New York, United States of America

Yumiko Umino

Affiliation Ophthalmology, SUNY Upstate Medical University, Syracuse, New York, United States of America

Jie Li

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Keqing Zhang

Affiliation Chongqing Key Laboratory of Ophthalmology, Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Song Mao

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Sanford L. Boye

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Li Liu

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Vince A. Chiodo

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Xuan Liu

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Wei Shi

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Ye Tao

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Bo Chang

Affiliation The Jackson Laboratory, Bar Harbor, Maine, United States of America

William W. Hauswirth

Affiliation Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

Competing Interests

WWH and the University of Florida have a financial interest in the use of AAV therapies, and own equity in a company (AGTC Inc.) that might, in the future, commercialize some aspects of this work. Research to Prevent Blindness, Inc., is a non-commercial company and this does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JP WWH. Performed the experiments: JP WTD XD BL DE YU JL KZ SM SLB LL VAC XL WS. Analyzed the data: JP BL DE. Contributed reagents/materials/analysis tools: BC WTD YT. Wrote the paper: JP WTD. Revision: JP WTD WWH.