About the Authors

Anastasia Malek

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Luz-Elena Núñez

Affiliation EntreChem SL, Edificio Científico Tecnológico, Campus El Cristo, Oviedo, Spain

Marco Magistri

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Lara Brambilla

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Sandra Jovic

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Giuseppina M. Carbone

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Francisco Morís

Affiliation EntreChem SL, Edificio Científico Tecnológico, Campus El Cristo, Oviedo, Spain

Carlo V. Catapano

carlo.catapano@irb.unisi.ch

Affiliations Institute of Oncology Research (IOR), Bellinzona, Switzerland, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

Competing Interests

Co-authors FM and LEN are employees and FM is a shareholder of EntreChem SL, the licensee company of the compounds described in the manuscript. All other authors have to declare that no competing interests exist.This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AM GMC FM CVC. Performed the experiments: AM LEN MM LB SJ. Analyzed the data: AM GMC FM CVC. Contributed reagents/materials/analysis tools: LEN FM GMC. Wrote the paper: AM FM GMC CVC.