Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)

Hyeon-Sook Suh; Namjong Choi; Leonid Tarassishin; Sunhee C. Lee

doi:10.1371/journal.pone.0035115

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Open Access

Peer-reviewed

Research Article

Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)

Hyeon-Sook Suh ,

* E-mail: hyeon-sook.suh@einstein.yu.edu

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Namjong Choi,

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Leonid Tarassishin,

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Sunhee C. Lee

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)

Hyeon-Sook Suh,
Namjong Choi,
Leonid Tarassishin,
Sunhee C. Lee

Published: April 11, 2012
https://doi.org/10.1371/journal.pone.0035115

About the Authors

Hyeon-Sook Suh

* E-mail: hyeon-sook.suh@einstein.yu.edu

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Namjong Choi

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Leonid Tarassishin

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Sunhee C. Lee

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HS SCL. Performed the experiments: HS NC LT. Analyzed the data: HS SCL. Contributed reagents/materials/analysis tools: HS SCL. Wrote the paper: HS SCL.

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Microglial cells
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Astrocytes
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Cytokines
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Small interfering RNA
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Macrophages
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Central nervous system
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Enzyme-linked immunoassays
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Inflammation
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