About the Authors

Renée Deehan

Affiliation Selventa, Cambridge, Massachusetts, United States of America

Pia Maerz-Weiss

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Natalie L. Catlett

Affiliation Selventa, Cambridge, Massachusetts, United States of America

Guido Steiner

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Ben Wong

Affiliation Selventa, Cambridge, Massachusetts, United States of America

Matthew B. Wright

matthew.wright@roche.com

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Gil Blander

Current address: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Affiliation Selventa, Cambridge, Massachusetts, United States of America

Keith O. Elliston

Current address: CHDI Foundation, Princeton, New Jersey, United States of America

Affiliation Selventa, Cambridge, Massachusetts, United States of America

William Ladd

Affiliation Selventa, Cambridge, Massachusetts, United States of America

Maria Bobadilla

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Jacques Mizrahi

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Carolina Haefliger

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Alan Edgar

† Deceased.

Affiliation F. Hoffmann-La Roche AG, Basel, Switzerland

Competing Interests

At the time of study design/implementation AE, CH, GS, JM, MBW and PM-W were employed by F. Hoffmann-La-Roche, Basel, Switzerland, while BW, GB, KOE, NLC, RD and WL were employed by Selventa, Cambridge, United States of America. This work was supported by F. Hoffmann-La Roche AG (www.roche.com). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MBW RD AE GS GB KOE. Performed the experiments: PM-W. Analyzed the data: MBW RD NLC GS BW GB KOE WL JM CH. Wrote the paper: MBW RD NLC. Performed statistical randomisation of samples during experimental design: GS. Scientific guidance: MBW RD NLC GB KOE MB CH.