About the Authors

Kimberly Brown Dahlman

Affiliation Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, New York, United States of America

Joel S. Parker

Affiliation Expression Analysis Inc., Durham, North Carolina, United States of America

Tambudzai Shamu

Affiliation Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, New York, United States of America

Haley Hieronymus

Affiliation Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, New York, United States of America

Caren Chapinski

Affiliation Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, New York, United States of America

Brett Carver

Affiliation Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Kenneth Chang

Affiliation Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Gregory J. Hannon

Affiliations Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Charles L. Sawyers

sawyersc@mskcc.org

Affiliations Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, New York, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

CLS is a co-inventor of MDV3100 and owns stock in Medivation. KBD was supported by AACR-Amgen, Inc. while this work was being performed. JSP is employed by Expression Analysis. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The remaining authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KBD HH BC CLS. Performed the experiments: KBD TS HH CC. Analyzed the data: KBD JSP BC CLS. Contributed reagents/materials/analysis tools: JSP KC GJH. Wrote the paper: KBD CLS. Critically revised the manuscript: KBD JSP TS HH CC BC KC GJH CLS.