About the Authors

Ashley J. Pratt

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Robert P. Rambo

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Pick-Wei Lau

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Ian J. MacRae

macrae@scripps.edu

Affiliation Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: This work was partly supported by Novartis Research Foundation. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AJP IJM. Performed the experiments: AJP PWL. Analyzed the data: AJP PWL RPR IJM. Wrote the paper: AJP IJM.