About the Authors

Arne Christians

Affiliation Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Christian Hartmann

hartmann.christian@mh-hannover.de

Affiliation Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany

Axel Benner

Affiliation Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Jochen Meyer

Affiliation Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Andreas von Deimling

Affiliations Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany

Michael Weller

Affiliations Department of Neurology, University Hospital Zurich, Zurich, Switzerland, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

Wolfgang Wick

Affiliations Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Neurooncology at the National Center for Tumour Diseases, Heidelberg University Hospital, Heidelberg, Germany, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

Markus Weiler

Affiliations Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Neurooncology at the National Center for Tumour Diseases, Heidelberg University Hospital, Heidelberg, Germany, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

Competing Interests

M. Weller has been a consultant to, and has received honoraria from MSD (former Schering-Plough, one company which manufactures temozolomide) and Oncomethylome Sciences. W. Wick has been a consultant to, and has received honoraria from MSD, Roche and Eli Lilly. All other authors have declared no conflicts of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AC CH AvD M. Weiler. Performed the experiments: AC JM. Analyzed the data: AC CH AB M. Weiler. Contributed reagents/materials/analysis tools: AVD M. Weiler WW. Wrote the paper: AC CH AB AvD M. Weller WW M. Weiler.