The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (PRNP) Are Responsible for Negative Feedback Regulation of the Prion Protein

Guangai Xue; Yoko Aida; Takashi Onodera; Akikazu Sakudo

doi:10.1371/journal.pone.0032870

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Peer-reviewed

Research Article

The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (PRNP) Are Responsible for Negative Feedback Regulation of the Prion Protein

Guangai Xue,

Affiliations Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan, Viral Infectious Diseases Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama, Japan
⨯
Yoko Aida,

Affiliation Viral Infectious Diseases Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama, Japan
⨯
Takashi Onodera,

Affiliation Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan
⨯
Akikazu Sakudo

* E-mail: sakudo@med.u-ryukyu.ac.jp

Affiliation Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
⨯

The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (PRNP) Are Responsible for Negative Feedback Regulation of the Prion Protein

Guangai Xue,
Yoko Aida,
Takashi Onodera,
Akikazu Sakudo

Published: March 7, 2012
https://doi.org/10.1371/journal.pone.0032870

About the Authors

Guangai Xue

Affiliations Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan, Viral Infectious Diseases Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama, Japan

Yoko Aida

Affiliation Viral Infectious Diseases Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama, Japan

Takashi Onodera

Affiliation Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan

Akikazu Sakudo

* E-mail: sakudo@med.u-ryukyu.ac.jp

Affiliation Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GX YA TO AS. Performed the experiments: GX AS. Analyzed the data: GX TO AS. Wrote the paper: GX TO AS.

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Transfection
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Plasmid construction
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Luciferase
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Feedback regulation
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Hyperexpression techniques
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Transcription factors
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Introns
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Gene expression
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