About the Authors

Christopher L. Reading

Affiliation Department of Scientific Development, Harbor Biosciences, San Diego, California, United States of America

James M. Frincke

Affiliation Department of Scientific Development, Harbor Biosciences, San Diego, California, United States of America

Steven K. White

swhite@harborbiosciences.com

Affiliation Department of Medicinal Chemistry, Harbor Biosciences, San Diego, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: All authors declare that they are employees of Harbor Biosciences who funded this study. All authors own stock in Harbor Biosciences. Harbor Biosciences owns US patent No. 7,776,845, which is related to HE3286. In addition, Dr. Frincke sits on the Board of Harbor Biosciences. HE3286 is in clinical development, but there is no marketed product to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SKW CLR JMF. Performed the experiments: SKW. Analyzed the data: SKW CLR JMF. Contributed reagents/materials/analysis tools: SKW. Wrote the paper: SKW CLR JMF.