About the Authors

Dag Sehlin

Dag.Sehlin@pubcare.uu.se

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Hillevi Englund

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Barbro Simu

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Mikael Karlsson

Affiliation Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden

Martin Ingelsson

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Fredrik Nikolajeff

Affiliation Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden

Lars Lannfelt

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Frida Ekholm Pettersson

Affiliation Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

Competing Interests

The authors have read the journal's policy and would like to report that Lars Lannfelt is a co-founder of Bioarctic Neuroscience AB. There are two patents associated with the present manuscript: 1. Patent number US2009/0258009 (inventors LL, DS, HE and FEP), describing the protofibril selective antibody mAb158, used for ELISA and immunoprecipitation. The antibody patent is not yet granted and is therefore a pending patent application. The number US 2009/0258009 was filed October 15, 2009. The application was also filed on September 27, 2007 as WO 2007/108756. 2. Patent number US7709695 (inventor LL), describing the APPArcSwe-transgenic investigated in the study. US 7709695 (B1) was granted on May 4, 2010. None of the other authors have any conflicts to report. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DS HE BS FEP MK. Performed the experiments: DS HE BS MK FEP. Analyzed the data: DS HE BS MK FEP LL. Contributed reagents/materials/analysis tools: DS HE FEP MI MK FN LL. Wrote the paper: DS HE FEP MI LL. Obtained permission for use of human material: MI.