About the Authors

Neil Auricchio

Contributed equally to this work with: Neil Auricchio, Izabela Malinowska

Affiliation Translational Medicine Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Izabela Malinowska

Contributed equally to this work with: Neil Auricchio, Izabela Malinowska

Affiliation Translational Medicine Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Reuben Shaw

Affiliation The Salk Institute, San Diego, California, United States of America

Brendan D. Manning

Affiliation Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

David J. Kwiatkowski

dk@rics.bwh.harvard.edu

Affiliation Translational Medicine Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJK. Performed the experiments: NA IM. Analyzed the data: NA IM DJK. Contributed reagents/materials/analysis tools: DJK. Wrote the paper: NA IM RS BM DJK. Suggested a trial of metformin in mice and provided information on dosage: RS. Suggested a trial of bortezomib in mice: BM.