About the Authors

Christian Czech

christian.czech@roche.com

Affiliation F. Hoffmann- La Roche, Pharmaceuticals Division, Basel, Switzerland

Peter Berndt

Affiliation F. Hoffmann- La Roche, Pharmaceuticals Division, Basel, Switzerland

Kristina Busch

Affiliation Badisch Anylene Und Soda Fabriques (BASF SE), Limburgerhof, Germany

Oliver Schmitz

Affiliation Metanomics, Berlin, Germany

Jan Wiemer

Affiliation Metanomics, Berlin, Germany

Veronique Most

Affiliation Forenap Pharma, Rouffach, France

Harald Hampel

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany

Jürgen Kastler

Affiliation Metanomics, Berlin, Germany

Hans Senn

Affiliation F. Hoffmann- La Roche, Pharmaceuticals Division, Basel, Switzerland

Competing Interests

The authors have read the journal's policy and have the following conflicts: CC, HS, and PB are employees of F. Hoffmann-La Roche. KB, OS, JW and JK were employed by metanomics during the time of the study. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CC PB KB HS JK. Performed the experiments: JK OS JW. Analyzed the data: OS JW. Contributed reagents/materials/analysis tools: HH VM. Wrote the paper: CC HS OS PB.